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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Dopamine beta-hydroxylase-Etamicastat hydrochloride
Etamicastat hydrochloride

Chemical Structure : Etamicastat hydrochloride

CAS No.: 677773-32-9

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Etamicastat hydrochloride (BIA 5-453)

货号: PC-22597Not For Human Use, Lab Use Only.

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent, peripherally selective and reversible dopamine-β-hydroxylase (DβH) inhibitor with IC50 of 107 nM, reduces the biosynthesis of norepinephrine (noradrenaline).

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5 mg ￥3480 In stock
10 mg ￥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent, peripherally selective and reversible dopamine-β-hydroxylase (DβH) inhibitor with IC50 of 107 nM, reduces the biosynthesis of norepinephrine (noradrenaline).

物理化学性质&存储条件

分子量 347.81
分子式 C14H16ClF2N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride

参考文献

1. Beliaev A, et al. J Med Chem. 2006 Feb 9;49(3):1191-7.

2. Loureiro AI, et al. Eur J Pharmacol. 2014 Oct 5;740:285-94.

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