Etacrynic acid |CAS:58-54-8 Probechem Biochemicals

Chemical Structure : Etacrynic acid

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Etacrynic acid (Edecrin)

货号: PC-61420Not For Human Use, Lab Use Only.

A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.

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生物&药学活性

A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.

Other Indication

Phase 2 Clinical

物理化学性质&存储条件

分子量	303.135
分子式	C13H12Cl2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI)

参考文献

1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195.

2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.

3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5.

4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.

Etacrynic acid (Edecrin)

生物&药学活性

物理化学性质&存储条件

参考文献

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Etacrynic acid (Edecrin)

生物&药学活性

物理化学性质&存储条件

参考文献

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