Estropipate | OATP1B1 inhibitor | Probechem Biochemicals

Chemical Structure : Estropipate

CAS No.: 7280-37-7

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Estropipate (Piperazine estrone sulfate)

货号: PC-20607Not For Human Use, Lab Use Only.

Estropipate is a potent, selective inhibitor of organic anion transporting polypeptides 1B1 (OATP1B1) with IC50 of 0.05 and 0.12 uM for human and cynomolgus monkey OATP1B1, respecitvely.

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25 mg	￥1980	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Estropipate is a potent, selective inhibitor of organic anion transporting polypeptides 1B1 (OATP1B1) with IC50 of 0.05 and 0.12 uM for human and cynomolgus monkey OATP1B1, respecitvely.
Estropipate shows weak inhibition for human and monkey OATP1B3, OATP2B1, sodium-taurocholate cotransporting polypeptide (NTCP), organic anion transporter 2, and organic cation transporter 1 with IC50 values ranging from 8.6 to 64.0 uM.

物理化学性质&存储条件

分子量	436.57
分子式	C18H22O5S.C4H10N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=CC(OS(=O)(O)=O)=C4)[C@@]3([H])CC1)C2=O.N5CCNCC5

参考文献

1. Zhang Y, et al. Mol Pharm. 2019 Jun 3;16(6):2342-2353.

Estropipate (Piperazine estrone sulfate)

生物&药学活性

物理化学性质&存储条件

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Estropipate (Piperazine estrone sulfate)

生物&药学活性

物理化学性质&存储条件

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