Estrone sulfamate |CAS:148672-09-7 Probechem Biochemicals

Chemical Structure : Estrone sulfamate

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Estrone sulfamate (Estrone 3-O-Sulfamate;EMATE)

货号: PC-61435Not For Human Use, Lab Use Only.

A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells.

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生物&药学活性

A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells; inhibits tissue E1-STS activity in rats by more than 95% at 10 mg/kg; exhibits potential applications in the treatment of ER-positive breast cancer and certain other conditions.

物理化学性质&存储条件

分子量	349.44
分子式	C18H23NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one

参考文献

1. Purohit A, et al. J Steroid Biochem Mol Biol. 1994 Jul;50(1-2):101-4.

2. Woo LW, et al. J Med Chem. 1998 Mar 26;41(7):1068-83.

3. Woo LL, et al. Chem Biol. 2000 Oct;7(10):773-91.

Estrone sulfamate (Estrone 3-O-Sulfamate;EMATE)

生物&药学活性

物理化学性质&存储条件

参考文献

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Estrone sulfamate (Estrone 3-O-Sulfamate;EMATE)

生物&药学活性

物理化学性质&存储条件

参考文献

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