Erlotinib |CAS:183321-74-6 Probechem Biochemicals

Chemical Structure : Erlotinib

CAS No.: 183321-74-6

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Erlotinib (NSC-718781;OSI-744;R-1415;CP-358774)

货号: PC-45893Not For Human Use, Lab Use Only.

Erlotinib (OSI-744; R-1415; CP-358774) is a potent, selective inhibitor of EGFR with IC50 of 2 nM.

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50 mg (Free Sample)	￥280	In stock
250 mg	￥980	In stock
500 mg	￥1380	In stock
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生物&药学活性

Erlotinib (OSI-744; R-1415; CP-358774) is a potent, selective inhibitor of EGFR with IC50 of 2 nM.
Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM.
Erlotinib inhibits the proliferation of DiFi human colon tumor cells at submicromolar concentrations in cell culture and blocks cell cycle progression at the G1 phase.
Erlotinib 100mg/kg completely prevents EGF-induced autophosphorylation of EGFR in human HN5 tumors growing as xenografts in athymic mice and of the hepatic EGFR of the treated mice; orally active.

物理化学性质&存储条件

分子量	393.4357
分子式	C22H23N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-

参考文献

1. Ng SS, et al. Mol Cancer Ther. 2002 Aug;1(10):777-83.

2. Moyer JD, et al. Cancer Res. 1997 Nov 1;57(21):4838-48.

3. Pollack VA, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):739-48.

Erlotinib (NSC-718781;OSI-744;R-1415;CP-358774)

生物&药学活性

物理化学性质&存储条件

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Erlotinib (NSC-718781;OSI-744;R-1415;CP-358774)

生物&药学活性

物理化学性质&存储条件

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