Erdafitinib (JNJ-42756493)

Chemical Structure : Erdafitinib

CAS No.: 1346242-81-6

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货号: PC-45537Not For Human Use, Lab Use Only.

Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4.
Erdafitinib (JNJ-42756493) shows rapid uptake into the lysosomal compartment of cells in culture, which is associated with prolonged inhibition of FGFR signaling; orally active.

物理化学性质&存储条件

分子量	446.5447
分子式	C25H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-

参考文献

1. Perera TPS, et al. Mol Cancer Ther. 2017 Jun;16(6):1010-1020.

2. Karkera JD, et al. Mol Cancer Ther. 2017 Apr 17. pii: molcanther.0518.2016.

3. Verstraete M, et al. BMC Cancer. 2015 Dec 16;15:946.