Epoxykynin

Chemical Structure : Epoxykynin

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货号: PC-21923Not For Human Use, Lab Use Only.

Epoxykynin is a potent, selective soluble epoxide hydrolase (sEH) with IC50 of 36 nM, inhibits the hydrolase activity of sEH and modulates kynurenine pathway.

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生物&药学活性

Epoxykynin is a potent, selective soluble epoxide hydrolase (sEH) with IC50 of 36 nM, inhibits the hydrolase activity of sEH and modulates kynurenine pathway.
potently inhibits kynurenine (Kyn) production with IC50 of 13.0 nM in IFN-γ-stimulated HeLa cells.
does not inhibit phosphatase activity of sEH and not affect the in vitro enzymatic activity of IDO1.
Epoxykynin inhibits the hydrolase activity of purified sEH very potently with IC50 of 6.7 nM.
Epoxykynin reduces Kyn levels in cells expressing IDO1.

物理化学性质&存储条件

分子量	445.28
分子式	C19H20BrF3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-bromo-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)-N-cycloheptylacetamide

参考文献

1. Lara Dötsch, et al. J Med Chem. 2024 Mar 12. doi: 10.1021/acs.jmedchem.3c02245.

Epoxykynin

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Epoxykynin

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