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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-Epothilone D
Epothilone D

Chemical Structure : Epothilone D

CAS No.: 189453-10-9

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Epothilone D (Desoxyepothilone B, dEpoB)

货号: PC-23848Not For Human Use, Lab Use Only.

Epothilone D (KOS 862) is a potent microtubule stabilizer, inhibits CCRF-CEM/VBL1000 cells (2,048-fold resistance to vinblastine) with IC50 of 2.9 nM.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Epothilone D (KOS 862) is a potent microtubule stabilizer, inhibits CCRF-CEM/VBL1000 cells (2,048-fold resistance to vinblastine) with IC50 of 2.9 nM.

物理化学性质&存储条件

分子量 491.69
分子式 C27H41NO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione

参考文献

1. Chou TC, et al. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8113-8.

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