Epetraborole hydrochloride (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates.
Epetraborole hydrochloride (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates.
Epetraborole has MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively.
A single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.
