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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Enoxacin
Enoxacin

Chemical Structure : Enoxacin

CAS No.: 74011-58-8

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Enoxacin (AT-2266, CI-919)

货号: PC-23990Not For Human Use, Lab Use Only.

Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml).
Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs.
Enoxacin shows potent activities against gram-positive and -negative bacteria.
Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bi

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml).
Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs.
Enoxacin shows potent activities against gram-positive and -negative bacteria.
Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing.

物理化学性质&存储条件

分子量 320.32
分子式 C15H17FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid

参考文献

1. Ge Shan, et al. Nat Biotechnol. 2008 Aug;26(8):933-40.

2. Sonia Melo, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9.

3. M Takei, et al. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7.

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