Enmetazobactam | β-lactamase inhibitor | Probechem Biochemicals

Chemical Structure : Enmetazobactam

CAS No.: 1001404-83-6

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Enmetazobactam (AAI-101, AAI101)

货号: PC-61972Not For Human Use, Lab Use Only.

Enmetazobactam (AAI-101) is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases.

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生物&药学活性

Enmetazobactam (AAI-101) is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases.
Enmetazobactam (AAI-101) is currently in clinical development as a combination with cefepime.
Enmetazobactam (AAI-101) reduces the MIC50 of cefepime against a collection of 223 cefepime-nonsusceptible isolates of the family Enterobacteriaceae from >64 mg/L to 0.125 mg/L.

物理化学性质&存储条件

分子量	314.32
分子式	C11H14N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,5R)-3-methyl-3-((1-methyl-1H-1,2,3-triazol-3-ium-3-yl)methyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

参考文献

1. Crandon JL, et al. Antimicrob Agents Chemother. 2015 May;59(5):2688-94.

2. Crandon JL, et al. Pathogens. 2015 Aug 18;4(3):620-5.

Enmetazobactam (AAI-101, AAI101)

生物&药学活性

物理化学性质&存储条件

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Enmetazobactam (AAI-101, AAI101)

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物理化学性质&存储条件

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