Enlicitide | PCSK9 inhibitor | Probechem Biochemicals

Chemical Structure : Enlicitide

CAS No.: 2407527-16-4

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Enlicitide (MK-0616, MK0616, Enlicitide chloride)

货号: PC-26304Not For Human Use, Lab Use Only.

规格	价格	库存
1 mg	￥5880	In stock
2 mg	￥8980	In stock
5 mg		Get quote
25 mg		Get quote

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生物&药学活性

Enlicitide (MK-0616) is a highly potent, orally bioavailable macrocyclic peptide inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with Ki of 5 pM, binds to the LDLR binding domain of PCSK9.
Enlicitide (MK-0616) inhibitsPCSK9 with an IC50 2.5 nM in human plasma.
Enlicitide (MK-0616) has no observed off-target activity at 10 µM in 122 receptor, ion channel, enzyme radioligand binding, and cellular assays in the Eurofins Cerep Panlabs screening panel.
Enlicitide (MK-0616) is not only able to reduce LDL-cholesterol, non-HDL-cholesterol, and apoB, but can also lower Lp(a).

物理化学性质&存储条件

分子量	1586.29
分子式	C82H110ClFN14O15
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ala-{Dpr}-Phe-Trp-Pro-Thr-Tyr-Pro(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)

参考文献

1. Li H, et al. J Am Chem Soc. 2025 Apr 2;147(13):11036-11048.

2. Johns DG, et al. Circulation. 2023 Jul 11;148(2):144-158.

Enlicitide (MK-0616, MK0616, Enlicitide chloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Enlicitide (MK-0616, MK0616, Enlicitide chloride)

生物&药学活性

物理化学性质&存储条件

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