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Endosomal trafficking inhibitor EGA

Chemical Structure : Endosomal trafficking inhibitor EGA

CAS No.: 415687-81-9

Endosomal trafficking inhibitor EGA (EGA)

货号: PC-70343Not For Human Use, Lab Use Only.

EGA is a potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EGA is a potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses.
EGA also delays lysosomal targeting and degradation of the EGF receptor, does not neutralize acidic organelles.
EGA is a powerful tool for the study of membrane trafficking and represents a class of host-targeted compounds for therapeutic development to treat infectious disease.

物理化学性质&存储条件

分子量 346.22
分子式 C16H16BrN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone

参考文献

1. Gillespie EJ, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12.

2. Jung ME, et al. ACS Med Chem Lett. 2014 Jan 21;5(4):363-7.

3. Slater LH, et al. Trends Microbiol. 2014 Feb;22(2):53-5.

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