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首页-小分子抑制剂&激动剂-Others-Clathrin-Endosidin 9
Endosidin 9

Chemical Structure : Endosidin 9

CAS No.: 693806-53-0

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Endosidin 9 (Clathrin inhibitor ES9)

货号: PC-72982Not For Human Use, Lab Use Only.

Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.
    Endosidin 9 (ES9) inhibits CME dynamics and organelle movement in the cytoplasm.
    Endosidin9 (ES9) inhibits clathrin-mediated endocytosis largely through cytoplasmic acidification.

    物理化学性质&存储条件

    分子量 363.2
    分子式 C10H7BrN2O4S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide

    参考文献

    1. Dejonghe W, et al. Nat Chem Biol. 2019 Jun;15(6):641-649.

    2. Dejonghe W, et al. Nat Commun. 2016 Jun 8;7:11710.

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