Endosidin17 | VPS35 inhibitor | Probechem Biochemicals

Chemical Structure : Endosidin17

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Endosidin17 (ES17)

货号: PC-73082Not For Human Use, Lab Use Only.

Endosidin17 (ES17) is a small molecule targets retromer component VPS35, binds to VPS35 Impairs interaction with RABG3f, causes dose-dependent stabilization of VPS35 with EC50 of 0.9 uM.

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生物&药学活性

Endosidin17 (ES17) is a small molecule targets retromer component VPS35, binds to VPS35 impairs interaction with RABG3f, causes dose-dependent stabilization of VPS35 with EC50 of 0.9 uM.
ES17 inhibited the vacuole accumulation of PIN2-GFP in the dark.
After ES17 treatment, PIN2-GFP accumulated in cytoplasmic structures that colocalized with the endocytic marker FM4-64 and the TGN/PVC marker ARA7-RFP in a concentration-dependent manner.
VPS35-RABG3f binding precedes the release of RABG3f–GTP to interact with the vacuolar homotypic fusion and vacuole protein sorting (HOPS) complex, which is required for fusion of late compartments with the tonoplast.

物理化学性质&存储条件

分子量	454.515
分子式	C22H18N2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-[3-hydroxy-2-oxo-5-phenyl-4-(2-thienylcarbonyl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate

参考文献

1. Rodriguez-Furlan C, et al. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21291-21301.

Endosidin17 (ES17)

生物&药学活性

物理化学性质&存储条件

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Endosidin17 (ES17)

生物&药学活性

物理化学性质&存储条件

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