Emprumapimod (PF-07265803) | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : Emprumapimod

CAS No.: 765914-60-1

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Emprumapimod (PF-07265803, PF 07265803)

货号: PC-73415Not For Human Use, Lab Use Only.

Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM.

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10 mg	￥7280	In stock
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生物&药学活性

Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM.
Emprumapimod (PF-07265803) (30 mg/kg, p.o.) inhibited LPS induced IL-6 and TNF-alpha by 91% and 95% in SCID-beige mice.
Emprumapimod (PF-07265803) (30 mg/kg, BID, PO) inhibited RPMI 8226 tumor growth by 72% as a single agent in MM xenograft models.
Emprumapimod (PF-07265803) inhibited LPS-induced phosphorylation of p38 in RPMI-8226 xenografts.

物理化学性质&存储条件

分子量	473.525
分子式	C24H29F2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(2S)-1-amino-4-(dimethylamino)-1-oxobutan-2-yl]-5-(2,4-difluorophenoxy)-1-(2-methylpropyl)indazole-6-carboxamide

参考文献

1. Dale Wright, et al. Blood (2006) 108 (11): 3478.

2. Antoine Muchir, et al. Hum Mol Genet. 2012 Oct 1;21(19):4325-33.

Emprumapimod (PF-07265803, PF 07265803)

生物&药学活性

物理化学性质&存储条件

参考文献

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Emprumapimod (PF-07265803, PF 07265803)

生物&药学活性

物理化学性质&存储条件

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