Empesertib (BAY1161909) | MPS1/TTK inhibitor | Probechem Biochemicals

Chemical Structure : Empesertib

CAS No.: 1443763-60-7

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Empesertib (BAY-1161909, BAY1161909)

货号: PC-43261Not For Human Use, Lab Use Only.

Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
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100 mg		Get quote

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生物&药学活性

Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM.
BAY1161909 inhibits only JNK2 and JNK3 more than 50% at 1 uM in Millipore panel (230 kinases).
BAY1161909 abrogates nocodazole-induced metaphase arrest in HeLa cells with IC50 of 56 nM, inhibits the proliferation of a panel tumor cell lines covering various cancer with mean IC50 of 160 nM.
BAY1161909 enhances the efficacy of antimitotic cancer drugs and shows potentially overcome resistance in vivo.

物理化学性质&存储条件

分子量	559.6113
分子式	C29H26FN5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	Benzeneacetamide, 4-fluoro-N-[4-[2-[[2-methoxy-4-(methylsulfonyl)phenyl]amino][1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]-α-methyl-, (αR)-

参考文献

1. Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.

2. Uitdehaag JCM, et al. J Mol Biol. 2017 Jul 7;429(14):2211-2230.

Empesertib (BAY-1161909, BAY1161909)

生物&药学活性

物理化学性质&存储条件

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Empesertib (BAY-1161909, BAY1161909)

生物&药学活性

物理化学性质&存储条件

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