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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-11β-HSD-Emodin
Emodin

Chemical Structure : Emodin

CAS No.: 518-82-1

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Emodin (Frangula Emodin)

货号: PC-24097Not For Human Use, Lab Use Only.

Emodin (Frangula emodin) is an anthraquinone derivative with anti-SARS-CoV activity, blocks the SARS coronavirus spike protein and ACE2 interaction, also inhibits casein kinase-2 (CK2), also activates Nrf2 and effectively targets PD pathology.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Emodin (Frangula emodin) is an anthraquinone derivative with anti-SARS-CoV activity, blocks the SARS coronavirus spike protein and ACE2 interaction, also inhibits casein kinase-2 (CK2), also activates Nrf2 and effectively targets PD pathology.
Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. 
Emodin ameliorates metabolic disorder in diet-induced obese mice.
Emodin treatment led to a significant upregulation of Nrf2 expression.

物理化学性质&存储条件

分子量 270.24
分子式 C15H10O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3,8-Trihydroxy-6-methylanthracene-9,10-dione

参考文献

1. Ying Feng, et al. Br J Pharmacol. 2010 Sep;161(1):113-26.

2. Jahan S, et al. Mol Neurobiol. 2025 Feb 20. doi: 10.1007/s12035-025-04762-3.

3. Tin-Yun Ho, et al. Antiviral Res. 2007 May;74(2):92-101.

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