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Emixustat

Chemical Structure : Emixustat

CAS No.: 1141777-14-1

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Emixustat (ACU-4429, ACU4429)

货号: PC-45684Not For Human Use, Lab Use Only.

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.

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10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Emixustat (ACU-4429) is a first in class small-molecule inhibitor of the visual cycle isomerase (RPE65) with IC50 of 4.4 nM.
Emixustat (ACU-4429 reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50 = 0.18 mg/kg).

物理化学性质&存储条件

分子量 263.3752
分子式 C16H25NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 43 mg/mL
Chemical Name/SMILES

Benzenemethanol, α-(2-aminoethyl)-3-(cyclohexylmethoxy)-, (αR)-

参考文献

1. Kiser PD, et al. Nat Chem Biol. 2015 Jun;11(6):409-15.

2. Bavik C, et al. PLoS One. 2015 May 13;10(5):e0124940.

3. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94.

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