Emivirine (MKC-442) | HIV-1 RT inhibitor | Probechem Biochemicals

Chemical Structure : Emivirine

CAS No.: 149950-60-7

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Emivirine (MKC-442, MKC442)

货号: PC-38744Not For Human Use, Lab Use Only.

Emivirine (MKC-442) is a highly potent and selective inhibitor of HIV-1 reverse transcriptase (RT) with IC50 of 8 nM, does not inhibit HIV-1 RNase H, other RTs, or DNA polymerase alpha.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

Emivirine (MKC-442) is a highly potent and selective inhibitor of HIV-1 reverse transcriptase (RT) with IC50 of 8 nM, does not inhibit HIV-1 RNase H, other RTs, or DNA polymerase alpha.
Emivirine (MKC-442) exhibits synergistic inhibition of HIV-1 RT with 3'-azido-2',3'-dideoxythymidine (AZT) 5'-triphosphate (AZT.TP).
Emivirine (MKC-442) potently inhibits HIV-1 (HTLV-IIIB strain) replication in MT-4 cells with IC50 and IC90 vaules of 15 and 98 nM, respectively, also inhibits HIV-1 replication in peripheral blood lymphocytes and monocyte-macrophages.
Emivirine (MKC-442) is equally active against zidovudine-resistant mutants and zidovudine-susceptible strains.

物理化学性质&存储条件

分子量	302.37
分子式	C17H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Benzyl-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione

参考文献

1. Yuasa S, et al. Mol Pharmacol. 1993 Oct;44(4):895-900.

2. Baba M, et al. Antimicrob Agents Chemother. 1994 Apr;38(4):688-92.

3. Brennan TM, et al. Antiviral Res. 1995 Mar;26(2):173-87.

Emivirine (MKC-442, MKC442)

生物&药学活性

物理化学性质&存储条件

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Emivirine (MKC-442, MKC442)

生物&药学活性

物理化学性质&存储条件

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