Embelin |CAS:550-24-3 Probechem Biochemicals

Chemical Structure : Embelin

CAS No.: 550-24-3

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Embelin (Embelic acid;Emberine;NSC-91874)

货号: PC-45289Not For Human Use, Lab Use Only.

Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties, specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM).

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50 mg	￥1480	In stock
100 mg	￥2380	In stock
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生物&药学活性

Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties, specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM).
Embelin has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo.
Embelin also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62 uM.

物理化学性质&存储条件

分子量	294.3859
分子式	C17H26O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl-

参考文献

1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.

2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9.

3. Lin Z, et al. Chem Biol. 2013 Feb 21;20(2):253-61.

Embelin (Embelic acid;Emberine;NSC-91874)

生物&药学活性

物理化学性质&存储条件

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Embelin (Embelic acid;Emberine;NSC-91874)

生物&药学活性

物理化学性质&存储条件

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