Elubrixin tosylate (SB-656933) | CXCR2 antagonist | Probechem Biochemicals

Chemical Structure : Elubrixin tosylate

CAS No.: 960495-43-6

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货号: PC-62990Not For Human Use, Lab Use Only.

Elubrixin tosylate (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

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Elubrixin tosylate (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

Elubrixin inhibits CXCL1-induced CD11b up-regulation on PMNs with IC50 of 26.07 nM in in vitro whole blood assay.

Elubrixin is active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.

分子量	635.503
分子式	C24H25Cl2FN4O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea tosylate

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3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80.

4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.