Elubrixin (SB-656933, GSK656933)

Chemical Structure : Elubrixin

CAS No.: 688763-64-6

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货号: PC-62989Not For Human Use, Lab Use Only.

Elubrixin (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Elubrixin (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
Elubrixin inhibits CXCL1-induced CD11b up-regulation on PMNs with IC50 of 26.07 nM in in vitro whole blood assay.
Elubrixin is active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.

物理化学性质&存储条件

分子量	463.305
分子式	C17H17Cl2FN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea

参考文献

1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.

2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9.

3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80.

4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.