Eltanexor (KPT-8602) | CRM1 inhibitor | Probechem Biochemicals

Chemical Structure : Eltanexor

CAS No.: 1642300-52-4

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Eltanexor (KPT-8602, KPT8602)

货号: PC-42150Not For Human Use, Lab Use Only.

Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less).
Eltanexor (KPT-8602) inhibits viability of human AML cell lines in vitro with IC50 of 20−211 nM, more active than the first-generation XPO1 inhibitor, selinexor.
Eltanexor (KPT-8602) exhibits greater anti-leukemic efficacy against both leukemic blasts and LICs in AML patient-derived xenograft models, with no effect on normal hematopoietic stem and progenitor cell (HSPC) frequency.

物理化学性质&存储条件

分子量	428.2913
分子式	C17H10F6N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 4.72 mg/mL
Chemical Name/SMILES	5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αE)-

参考文献

1. Etchin J, et al. Leukemia. 2017 Jan;31(1):143-150.

2. Hing ZA, et al. Leukemia. 2016 Dec;30(12):2364-2372.

3. Vercruysse T, et al. Clin Cancer Res. 2017 May 15;23(10):2528-2541.

Eltanexor (KPT-8602, KPT8602)

生物&药学活性

物理化学性质&存储条件

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Eltanexor (KPT-8602, KPT8602)

生物&药学活性

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