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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-ASBT Transporter (SLC10A2)-Elobixibat hydrate
Elobixibat hydrate

Chemical Structure : Elobixibat hydrate

CAS No.: 1633824-78-8

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Elobixibat hydrate (A3309, AZD7806)

货号: PC-23610Not For Human Use, Lab Use Only.

Elobixibat hydrate (A3309, AZD7806, AJG-533) is an orally available, potent and selective apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2) inhibitor with IC50 of 0.53 nM, 0.13 nM, and 5.8 nM for human, mouse, and canine IBAT respectively.

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elobixibat hydrate (A3309, AZD7806, AJG-533) is an orally available, potent and selective apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2) inhibitor with IC50 of 0.53 nM, 0.13 nM, and 5.8 nM for human, mouse, and canine IBAT respectively.

物理化学性质&存储条件

分子量 713.91
分子式 C36H47N3O8S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(2-(2-((3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-8-yl)oxy)acetamido)-2-phenylacetyl)glycine hydrate

参考文献

1. Chey WD, et al. Gastroenterol. 2014 May;109(5):782.

2. Wong BS, et al. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84.

3. Wong BS, et al. Am J Gastroenterol. 2011 Dec;106(12):2154-64.

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