Elobixibat (A3309, AZD7806, AJG-533)

Chemical Structure : Elobixibat

CAS No.: 439087-18-0

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货号: PC-61407Not For Human Use, Lab Use Only.

Elobixibat (A3309, AZD7806, AJG-533) is an orally available, potent and selective apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2) inhibitor with IC50 of 0.53 nM, 0.13 nM, and 5.8 nM for human, mouse, and canine IBAT respectively.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Elobixibat (A3309, AZD7806, AJG-533) is an orally available, potent and selective apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2) inhibitor with IC50 of 0.53 nM, 0.13 nM, and 5.8 nM for human, mouse, and canine IBAT respectively.

物理化学性质&存储条件

分子量	695.89
分子式	C36H45N3O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Glycine, (2R)-N-[[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycyl- (9CI)

参考文献

1. Chey WD, et al. Gastroenterol. 2014 May;109(5):782.

2. Wong BS, et al. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84.

3. Wong BS, et al. Am J Gastroenterol. 2011 Dec;106(12):2154-64.