Eliprodil | GluN2B antagonist | Probechem Biochemicals

Chemical Structure : Eliprodil

CAS No.: 119431-25-3

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Eliprodil (SL-820715)

货号: PC-43279Not For Human Use, Lab Use Only.

Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor (GluN2B) antagonist with IC50 of 1 uM, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor (GluN2B) antagonist with IC50 of 1 uM, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM).
Eliprodil inhibits [3H]norepinephrine release from cortical and hippocampal slices but enhances the basal efflux of endogenous and tritiated dopamine from striatal slices.
Eliprodil also blocks the uptake of [3H]dopamine into striatal synaptosomes with IC50 of 1.5 uM.
Eliprodil reduces the volume of infarction in models of focal cerebral ischemia.

物理化学性质&存储条件

分子量	347.8541
分子式	C20H23ClFNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-

参考文献

1. Woodward JJ, et al. Eur J Pharmacol. 1992 Jan 21;210(3):265-70.

2. Carter CJ, et al. J Pharmacol Exp Ther. 1990 May;253(2):475-82.

3. Carter C, et al. Eur J Pharmacol. 1989 May 30;164(3):611-2.

4. Bath CP, et al. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.

Eliprodil (SL-820715)

生物&药学活性

物理化学性质&存储条件

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Eliprodil (SL-820715)

生物&药学活性

物理化学性质&存储条件

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