Elimusertib hydrochloride (BAY1895344) | ATR inhibitor

Chemical Structure : Elimusertib hydrochloride

CAS No.:

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Elimusertib hydrochloride (BAY1895344 hydrochloride)

货号: PC-70146Not For Human Use, Lab Use Only.

Elimusertib hydrochloride (BAY1895344) is a potent, selective, orally active ATR inhibitor with low-nanomolar potency (IC50=7 nM).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Elimusertib hydrochloride (BAY1895344) is a potent, selective, orally active ATR inhibitor with low-nanomolar potency (IC50=7 nM).
BAY1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with mean IC50 of 78 nM.
BAY1895344 inhibits hydroxyurea-induced H2AX phosphorylation, exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models.

物理化学性质&存储条件

分子量	411.894
分子式	C20H22ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride

参考文献

1. Ulrich Lücking, et al. J Med Chem. 2020 Jul 9;63(13):7293-7325.

Elimusertib hydrochloride (BAY1895344 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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Elimusertib hydrochloride (BAY1895344 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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