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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-CFTR-Elexacaftor
Elexacaftor

Chemical Structure : Elexacaftor

CAS No.: 2216712-66-0

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Elexacaftor (VX-445, WHO11180)

货号: PC-73172Not For Human Use, Lab Use Only.

Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector and modulator for cystic fibrosis treatment.

规格 价格 库存 数量
1 mg ￥980 In stock
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
50 mg ￥7580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector and modulator for cystic fibrosis treatment.

物理化学性质&存储条件

分子量 597.658
分子式 C26H34F3N7O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-((1,3-Dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide

参考文献

1. Keating D, et al. N Engl J Med. 2018 Oct 25;379(17):1612-1620.

2. Taylor-Cousar JL, et al. ERJ Open Res. 2019 Jun 17;5(2):00082-2019.

3. Middleton PG, et al. N Engl J Med. 2019 Nov 7;381(19):1809-1819.

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