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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Elevenostat
Elevenostat

Chemical Structure : Elevenostat

CAS No.: 1454902-97-6

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Elevenostat (JB3-22)

货号: PC-72094Not For Human Use, Lab Use Only.

Elevenostat (JB3-22) is a selective HDAC11 inhibitor with IC50 of 0.235 uM.

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25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elevenostat (JB3-22) is a selective HDAC11 inhibitor with IC50 of 0.235 uM.
Elevenostat (JB3-22) reversed the inhibitory effects of HDAC11 at the Foxp3 promoter in vitro, also partially reversed the inhibitory effect of HDAC11 on p300-induced Foxp3 acetylation at lysine 31.
HDAC11 targeting with Elevenostat (JB3-22) for post-transplant can promote Treg suppressive activity and lead to long-term allograft survival.

物理化学性质&存储条件

分子量 315.329
分子式 C16H17N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Hydroxy-4-((3-(2-methoxyphenyl)ureido)methyl)benzamide

参考文献

1. Kutil Z, et al. ACS Omega. 2019 Nov 15;4(22):19895-19904.

2. Mostofa A, et al. JCI Insight. 2021 Dec 22;6(24):e151713.

3. Liyan Sui, et al. Cell Cycle. 2020 Feb;19(3):354-362.

4. Huang J, et al. Sci Rep. 2017;7:8626.

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