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首页-小分子抑制剂&激动剂-Apoptosis-Apoptosis Inducer-Elesclomol
Elesclomol

Chemical Structure : Elesclomol

CAS No.: 488832-69-5

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Elesclomol (STA-4783;STA4783;STA 4783)

货号: PC-42855Not For Human Use, Lab Use Only.

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells; selectively kills cisplatin-resistant tumor cells through increased ROS, markedly enhances the therapeutic index of paclitaxel against human tumor xenograft models.

Ovarian Cancer

Phase 2 Clinical

物理化学性质&存储条件

分子量 400.5177
分子式 C19H20N4O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 22 mg/mL
Chemical Name/SMILES

Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]

参考文献

1. Berkenblit A, et al. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):584-90.

2. Kirshner JR, et al. Mol Cancer Ther. 2008 Aug;7(8):2319-27.

3. Wangpaichitr M, et al. Cancers (Basel). 2009;1(1):23-38.

4. Kluza J, et al. Cancer Res. 2012 Oct 1;72(19):5035-47.

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