Eleclazine (GS6615) hydrochloride | Sodium current inhibitor

Chemical Structure : Eleclazine hydrochloride

CAS No.: 1448754-43-5

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Eleclazine hydrochloride (GS-6615 hydrochloride, GS6615 hydrochloride)

货号: PC-45068Not For Human Use, Lab Use Only.

A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
Eleclazine (GS6615) is 42 times more potent than Ranolazine in reducing ischemic burden in vivo (EC50=190 nM).

物理化学性质&存储条件

分子量	451.8262
分子式	C21H17ClF3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1)

参考文献

1. Zablocki JA, et al. J. Med. Chem., 2016, 59 (19), pp 9005–9017

2. Fuller H, et al. Heart Rhythm. 2016 Aug;13(8):1679-86.

3. Bacic D, et al. Heart Rhythm. 2017 Mar;14(3):448-454.

Eleclazine hydrochloride (GS-6615 hydrochloride, GS6615 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Eleclazine hydrochloride (GS-6615 hydrochloride, GS6615 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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