Elbasvir | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : Elbasvir

CAS No.: 1370468-36-2

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Elbasvir (MK-8742, MK8742)

货号: PC-21353Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
1 g		Get quote

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生物&药学活性

Elbasvir (MK-8742) is a potent, tetracyclic indole-based HCV NS5A inhibitor, shows broad HCV genotype activity with IC50 of 0.003, 0.003, 0.004, 0.5, 2.4 nM for genotype 1b, 2a, 1a, 1aL31V and 1aY93H, respectively.
Elbasvir (MK-8742) shows an increased potency against clinically relevant resistance variants.
Elbasvir (MK-8742) exhibits antiviral activity against several HCV genotypes (including 1a, 1b, 2a, 3a, 4a) with decreased potency against genotype 2b.

物理化学性质&存储条件

分子量	882.02
分子式	C49H55N9O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dimethyl ((2S,2'S)-((2S,2'S)-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-1,2-diyl))dicarbamate

参考文献

1. Coburn CA, et al. ChemMedChem. 2013 Dec;8(12):1930-40.

Elbasvir (MK-8742, MK8742)

生物&药学活性

物理化学性质&存储条件

参考文献

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Elbasvir (MK-8742, MK8742)

生物&药学活性

物理化学性质&存储条件

参考文献

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