Elatol | eIF4A1 inhibitor | Probechem Biochemicals

Chemical Structure : Elatol

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Elatol (NSC 341593)

货号: PC-35162Not For Human Use, Lab Use Only.

Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.

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生物&药学活性

Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
Elatol (NSC 341593) binds in a 2:1 ratio to eIF4A1 (Kd=1.98 uM) and disrupts helicase activity, Elatol is active against eIF4A1’s ATP hydrolysis at 16.4 uM.
Elatol is less potent in vitro than the well-studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at ~100X relative dosing, leading to significant activity against lymphoma xenografts.

物理化学性质&存储条件

分子量	333.694
分子式	C15H22BrClO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4R,6R)-4-bromo-10-chloro-5,5,9-trimethyl-1-methylidenespiro[5.5]undec-9-en-3-ol

参考文献

1. Peters TL, et al. Clin Cancer Res. 2018 May 29. pii: clincanres.3645.2017.

Elatol (NSC 341593)

生物&药学活性

物理化学性质&存储条件

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Elatol (NSC 341593)

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物理化学性质&存储条件

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