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首页-小分子抑制剂&激动剂-Autophagy-Elaiophylin
Elaiophylin

Chemical Structure : Elaiophylin

CAS No.: 37318-06-2

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Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B)

货号: PC-63057Not For Human Use, Lab Use Only.

Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B) is a macrodiolide antibiotic and autophagy inhibitor that promotes autophagosome accumulation.

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1 mg ￥3280 In stock
2 mg ￥5280 In stock
5 mg ￥8580 In stock
10 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B) is a macrodiolide antibiotic that shows in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50=370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50=870 ng/ml).
Elaiophylin  also is a novel autophagy inhibitor that promotes autophagosome accumulation but blocks autophagic flux by attenuating lysosomal cathepsin activity, resulting in the accumulation of SQSTM1/p62 in various cell lines.

物理化学性质&存储条件

分子量 1025.3
分子式 C54H88O18
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3E,5E,7S,8S,11E,13E,15S,16S)-8,16-bis[(2S,3R,4S)-4-[(2R,4R,5R,6R)-4-[(2R,4S,5S,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-2-hydroxy-6-methyloxan-2-yl]-3-hydroxypentan-2-yl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione

参考文献

1. Otoguro K, et al. J Antibiot (Tokyo). 2010 May;63(5):275-7.

2. Zhao X, et al. Autophagy. 2015;11(10):1849-63.

3. Wang G, et al. Cancer Biol Ther. 2017 Jul 18:1-12.

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