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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-Elafibranor
Elafibranor

Chemical Structure : Elafibranor

CAS No.: 923978-27-2

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Elafibranor (GFT-505, GFT505)

货号: PC-45067Not For Human Use, Lab Use Only.

Elafibranor (GFT-505) is a potent dual PPAR α/δ agonist with EC50 of 45 and 175 nM, respectively.

规格 价格 库存 数量
5 mg (Free Sample) ￥280 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Elafibranor (GFT-505) is a potent dual PPAR α/δ agonist with EC50 of 45 and 175 nM, respectively.
Elafibranor (GFT-505) demonstrates liver-protective effects on steatosis, inflammation, and fibrosis in animal models of NAFLD/NASH and liver fibrosis.
Elafibranor (GFT-505) significantly reduces fasting plasma triglycerides and increases HDL cholesterol, also reduces γ glutamyl transferase levels.

物理化学性质&存储条件

分子量 384.4886
分子式 C22H24O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methyl-

参考文献

1. Liu ZM, et al. Expert Opin Investig Drugs. 2015 May;24(5):611-21.

2. Cariou B, et al. Diabetes Care. 2011 Sep;34(9):2008-14.

3. Staels B, et al. Hepatology. 2013 Dec;58(6):1941-52.

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