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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Elacytarabine
Elacytarabine

Chemical Structure : Elacytarabine

CAS No.: 188181-42-2

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Elacytarabine (CP-4055;CP4055;ELACYT)

货号: PC-35560Not For Human Use, Lab Use Only.

Elacytarabine (CP-4055, CP4055, ELACYT) is a fatty acid derivative of cytarabine with potential antineoplastic activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Elacytarabine (CP-4055, CP4055, ELACYT) is a fatty acid derivative of cytarabine with potential antineoplastic activity; CP-4055 is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, CP-4055 shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine.

Chemotherapeutic Agents

Phase 2 Clinical

物理化学性质&存储条件

分子量 507.672
分子式 C27H45N3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[(2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (E)-octadec-9-enoate

参考文献

1. Adams DJ, et al. Leuk Lymphoma. 2008 Apr;49(4):786-97.

2. Rubas W, et al. Int J Cancer. 1986 Jan 15;37(1):149-54.

3. Pignata S, et al. Cancer Chemother Pharmacol. 2011 Nov;68(5):1347-53.

4. Giles FJ, et al. Leukemia. 2012 Jul;26(7):1686-9.

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