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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -Efonidipine hydrochloride monoethanolate
Efonidipine hydrochloride monoethanolate

Chemical Structure : Efonidipine hydrochloride monoethanolate

CAS No.: 111011-76-8

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Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate)

货号: PC-43070Not For Human Use, Lab Use Only.

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation.

规格 价格 库存 数量
10 mg ￥750 In stock
50 mg ￥2550 In stock
100 mg ￥4550 In stock
500 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation; increases coronary blood flow by blocking L & T-type calcium channels and attenuates myocardial ischaemia, lowers blood pressure in cerebral resistance vessels and prevents hypertension induced brain damage; increases glomerular filtration rate without increasing intra-glomerular pressure and filtration fraction.

物理化学性质&存储条件

分子量 714.1846
分子式 C36H45ClN3O8P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 8.5 mg/mL
Chemical Name/SMILES

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, hydrochloride, compd. with 2-[phenyl(phenylmethyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2

参考文献

1. Masuda Y, et al. Arch Int Pharmacodyn Ther. 1990 Mar-Apr;304:247-64.

2. Tamura T, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):405-10.

3. Shudo C, et al. Gen Pharmacol. 1994 Nov;25(7):1451-8.

4. Yamashita T, et al. Jpn J Pharmacol. 1991 Nov;57(3):337-48.

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