Efipladib |CAS:381683-94-9 Probechem Biochemicals

Chemical Structure : Efipladib

加入收藏

Efipladib (PLA902, PLA-902)

货号: PC-61845Not For Human Use, Lab Use Only.

Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition.
Efipladib (PLA 902) shows efficacy in multiple acute and chronic prostaglandin and leukotriene dependent in vivo models.
Efipladib (PLA 902) also decreases basal and EGF-stimulated AKT phosphorylation and proliferation in HT-29 cancer cells, reduces xenograft growth by >90% with a concomitant decrease in AKT phosphorylation in mice (10 mg/kg, i.p. daily, >14 days).

物理化学性质&存储条件

分子量	746.14
分子式	C40H35Cl3N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(5-chloro-2-(2-(((3,4-dichlorobenzyl)sulfonyl)aMino)ethyl)-1-(diphenylMethyl)-1H-indol-3-yl)propyl)benzoic acid

参考文献

1. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413.

2. Nickerson-Nutter CL, et al. Neuropharmacology. 2011 Mar;60(4):633-41.

3. Zheng Z, et al. Oncotarget. 2014 Dec 15;5(23):12304-16.

Efipladib (PLA902, PLA-902)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Efipladib (PLA902, PLA-902)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.