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首页-抗体和重组蛋白-Biosimilar Antibody-Efgartigimod
Efgartigimod

Chemical Structure : Efgartigimod

CAS No.: 1821402-21-4

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Efgartigimod (ARGX-113, ARGX113)

货号: PC-26842Not For Human Use, Lab Use Only.

Efgartigimod (ARGX-113) is a human IgG1–derived (hIgG1-derived) Fc fragment (residues D220-K447) neonatal Fc receptor (FcRn) antagonist.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Efgartigimod (ARGX-113) is a human IgG1–derived (hIgG1-derived) Fc fragment (residues D220-K447) neonatal Fc receptor (FcRn) antagonist.
Efgartigimod has equilibrium dissociation constants for human FcRn of 14.2 nM and 320 nM at pH 6.0 and pH 7.4, respectively.
Efgartigimod induces specific, profound, and sustained reduction of serum IgG levels.

物理化学性质&存储条件

分子量
分子式 51.28 kDa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Ulrichts P, et al. J Clin Invest. 2018 Oct 1;128(10):4372-4386.

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