Efavirenz |CAS:154598-52-4 Probechem Biochemicals

Chemical Structure : Efavirenz

CAS No.: 154598-52-4

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Efavirenz (DMP 266, EFV, L-743726)

货号: PC-42660Not For Human Use, Lab Use Only.

Efavirenz (DMP 266, EFV) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.

规格	价格	库存
50 mg	￥880	In stock
100 mg	￥1380	In stock
250 mg	￥2180	In stock
1 g		Get quote

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生物&药学活性

Efavirenz (DMP 266, EFV) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.
Efavirenz (DMP 266, EFV) inhibits HIV-1 replicative spread in cell culture with IC95 of 1.5 nM.
Efavirenz (DMP 266, EFV) exhibits activity against a panel of NNRTI-resistant mutant viruses.
Efavirenz (DMP 266, EFV) possesses good oral bioavailability and pharmacokinetics.
Efavirenz (DMP 266, EFV) induces autophagy and mitochondrial changes in neurons.

物理化学性质&存储条件

分子量	315.675
分子式	C14H9ClF3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 38 mg/mL
Chemical Name/SMILES	2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-

参考文献

1. Young SD, et al. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5.

2. Purnell PR, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):250-8.

3. Bertrand L, et al. Mol Pharmacol. 2015 Aug;88(2):304-15.

Efavirenz (DMP 266, EFV, L-743726)

生物&药学活性

物理化学性质&存储条件

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Efavirenz (DMP 266, EFV, L-743726)

生物&药学活性

物理化学性质&存储条件

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