Edonerpic maleate (T-817MA)

Chemical Structure : Edonerpic maleate

CAS No.: 519187-97-4

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货号: PC-35371Not For Human Use, Lab Use Only.

Edonerpic maleate (T-817MA) is a neurotrophic agent that can protects neuronal cells and modifies their morphology, binds to collapsin-response-mediator-protein 2 (CRMP2) and inhibits amyloid-β peptides (Aβ).

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Edonerpic maleate (T-817MA) is a neurotrophic agent that can protects neuronal cells and modifies their morphology, binds to collapsin-response-mediator-protein 2 (CRMP2) and inhibits amyloid-β peptides (Aβ).
Edonerpic maleate binds to collapsin-response-mediator-protein 2 (CRMP2) with Kd of 7.35 x 10−4 M.
Edonerpic maleate attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons.
Edonerpic maleate ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide.

物理化学性质&存储条件

分子量	407.481
分子式	C20H25NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate

参考文献

1. Abe H, et al. Science. 2018 Apr 6;360(6384):50-57.

2. Hirata K, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):252-9.

3. Fukushima T, et al. Biochem Biophys Res Commun. 2011 Apr 22;407(4):730-4.

4. Kimura T, et al. Br J Pharmacol. 2009 Jun;157(3):451-63.