Edicotinib (JNJ-40346527) | CSF1R inhibitor | Probechem Biochemicals

Chemical Structure : Edicotinib

CAS No.: 1142363-52-7

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Edicotinib (JNJ-40346527, JNJ 40346527, PRV 6527, JNJ-527)

货号: PC-61373Not For Human Use, Lab Use Only.

Edicotinib (JNJ-40346527, PRV 6527) is a potent, selective, orally bioavailable CSF-1R inhibitor with IC50 of 3.2 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Edicotinib (JNJ-40346527, PRV 6527) is a potent, selective, orally bioavailable CSF-1R inhibitor with IC50 of 3.2 nM.
Edicotinib (JNJ-40346527) shows weak affinity for KIT and FLT3 (IC50= 20 nM and 190 nM, respectively).
Edicotinib (JNJ-40346527) reduces the levels of EMT-associated genes, stem cell markers and chemoresistance genes, produces strong chemo-sensitizing effects in vitro and in vivo.

物理化学性质&存储条件

分子量	461.61
分子式	C27H35N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide

参考文献

1. von Tresckow B, et al. Clin Cancer Res. 2015 Apr 15;21(8):1843-50.

2. Genovese MC, et al. J Rheumatol. 2015 Oct;42(10):1752-60.

3. Pass HI, et al. Oncotarget. 2016 Aug 30;7(35):56408-56421.

4. Kumar V, et al. Cancer Cell. 2017 Nov 13;32(5):654-668.e5.

Edicotinib (JNJ-40346527, JNJ 40346527, PRV 6527, JNJ-527)

生物&药学活性

物理化学性质&存储条件

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Edicotinib (JNJ-40346527, JNJ 40346527, PRV 6527, JNJ-527)

生物&药学活性

物理化学性质&存储条件

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