Ecopladib |CAS:381683-92-7 Probechem Biochemicals

Chemical Structure : Ecopladib

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Ecopladib (PLA725, PLA-725)

货号: PC-61844Not For Human Use, Lab Use Only.

Ecopladib (PLA 725) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 0.15 and 0.11 uM in GLU micelle and rat whole blood assays, respectively.

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生物&药学活性

Ecopladib (PLA 725) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 0.15 and 0.11 uM in GLU micelle and rat whole blood assays, respectively.
Ecopladib (PLA 725) displays no activity toward the closely related β and γ isoforms, and the unrelated type II sPLA2.
Ecopladib (PLA 725) inhibits PAF production and both prostaglandin and leukotriene pathways.
Ecopladib (PLA 725) demonstrates oral efficacy in the rat carrageenan air pouch (ED50=8mg/kg) and rat carrageenan-induced paw edema (EC50=40mg/kg) models.

物理化学性质&存储条件

分子量	748.112
分子式	C39H33Cl3N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-[1-benzhydryl-5-chloro-2-[2-[(3,4-dichlorophenyl)methylsulfonylamino]ethyl]indol-3-yl]ethoxy]benzoic acid

参考文献

1. Lee KL, et al. J Med Chem. 2007 Mar 22;50(6):1380-400.

Ecopladib (PLA725, PLA-725)

生物&药学活性

物理化学性质&存储条件

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Ecopladib (PLA725, PLA-725)

生物&药学活性

物理化学性质&存储条件

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