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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -Ebselen
Ebselen

Chemical Structure : Ebselen

CAS No.: 60940-34-3

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Ebselen (CCG-39161, PI-1005, PZ-51 )

货号: PC-20690Not For Human Use, Lab Use Only.

Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM.

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100 mg ￥1880 In stock
200 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM.
Ebsele covalently binds to C145 of the catalytic SARS CoV-2 Mpro, shows strong antiviral effects at a concentration of 10 μM in COVID-19 virus infected Vero cells.
Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process.
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines.
Ebselen also is a first-in-class inhibitor of the YTHDF m6A-binding domain, engages YTHDF proteins within cells, interfering with their mRNA binding.

物理化学性质&存储条件

分子量 274.18
分子式 C13H9NOSe
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-phenylbenzo[d][1,2]selenazol-3(2H)-one

参考文献

1. Liang Q, et al.et al. Front Neurosci. 2019 Oct 14;13:1073.

2. Micaelli M, et al. ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):872-891.

3. Jin Z, et al. et al. Nature. 2020 Apr 9.

4. Hanavan PD, et al. Oncotarget. 2015 Jul 30;6(21):18418-28.

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