Ebio3

Chemical Structure : Ebio3

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货号: PC-23869Not For Human Use, Lab Use Only.

Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM.

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生物&药学活性

Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM.
Ebio3 shows no effect on the KCNQ1 channel, weakly inhibits KCNQ3, KCNQ4 and KCNQ5 (IC50=15-196 nM), and negligible inhibitory effects on K+, Na+, Ca2+ and H+ channels, including hERG, Kv4.2, TREK1, TREK2, TASK3, NaV1.1, CaV3.2 and Hv1.
Ebio3 inhibits KCNQ2 pathogenic GOF variants, 10 nM Ebio3 resulted in approximately 80% or greater reduction in the outward current for R75C and I238L mutations.

物理化学性质&存储条件

分子量	363.41
分子式	C19H23F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(7-(difluoromethoxy)-1-(prop-2-yn-1-yl)-1H-indazol-3-yl)-2-propylpentanamide

参考文献

1. Li J, et al. Nat Chem Biol. 2025 Jan 15. doi: 10.1038/s41589-024-01834-8.

Ebio3

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Ebio3

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