EZ-482 | ApoE ligand, ApoE inhibitor | Probechem Biochemicals

Chemical Structure : EZ-482

CAS No.: 1016456-76-0

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EZ-482 (EZ482)

货号: PC-27560Not For Human Use, Lab Use Only.

EZ-482 is a small molecule ligand of Apolipoprotein E (ApoE), binds to the C-terminal domains of both ApoE3 and ApoE4 with KD of approximately 8 μM, blocks heparin binding to the N-terminal domain.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

EZ-482 is a small molecule ligand of Apolipoprotein E (ApoE), binds to the C-terminal domains of both ApoE3 and ApoE4 with KD of approximately 8 μM, blocks heparin binding to the N-terminal domain.
EZ-482 overcomes ICB resistance induced by M2-exo administration.
EZ-482 reverses ICB resistance induced by M2-exo in preclinical tumor models.
EZ-482 effectively prevented APPNEV-induced synaptic formation impairment, APPNEV-mediated downregulation of synaptic proteins, and the APPNEV-induced decrease in synaptic maturity.
EZ-482 may affect apoE binding both the LRP-1 and LDL receptors.

物理化学性质&存储条件

分子量	498.94
分子式	C23H19ClN4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(N-(3-Chlorophenyl)sulfamoyl)-2-hydroxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide

参考文献

1. Mondal T, et al. Biochemistry. 2016 May 10;55(18):2613-21.

2. Zheng N, et al. Oncoimmunology. 2023 May 13;12(1):2210959.

EZ-482 (EZ482)

生物&药学活性

物理化学性质&存储条件

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EZ-482 (EZ482)

生物&药学活性

物理化学性质&存储条件

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