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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-EXEL-8232
EXEL-8232

Chemical Structure : EXEL-8232

CAS No.:

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EXEL-8232 (EXEL 8232;EXEL8232)

货号: PC-61277Not For Human Use, Lab Use Only.

A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A potent and selective, orally bioavailable JAK2 inhibitor with IC50 of 2 nM; displays >10-fold selectivity over JAK1, JAK3 and Tyk2, and 56 other tyrosine and serinethreonine kinases; inhibits proliferation of SET-2 and UKE-1 cells with IC50 of 177 and 146 nM respectively; effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Wernig G, et al. Leukemia. 2012 Apr;26(4):720-7.

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