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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -EX-527
EX-527

Chemical Structure : EX-527

CAS No.: 49843-98-3

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EX-527 (Selisistat, EX527)

货号: PC-21165Not For Human Use, Lab Use Only.

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with IC50 of 123 nM for SirT1.

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10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg ￥2480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with IC50 of 123 nM for SirT1.
Selisistat (EX-527) (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.
Selisistat (EX-527) (5 and 20 mg/kg, PO, daily) is protective in the R6/2 mouse model of Huntington's disease (HD).

物理化学性质&存储条件

分子量 248.71
分子式 C13H13ClN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

参考文献

1. Smith MR, et al. Hum Mol Genet. 2014;23(11):2995-3007.

2. Napper AD, et al. J Med Chem. 2005;48(25):8045-8054.

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