EW-7197 (Vactosertib) | ALK5 inhibitor | Probechem Biochemicals

Chemical Structure : EW-7197

CAS No.: 1352608-82-2

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EW-7197 (Vactosertib, EW7197, TEW-7197)

货号: PC-45749Not For Human Use, Lab Use Only.

EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (ALK5) with IC50 of 11 nM.

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10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-β type I receptor kinase (ALK5) with IC50 of 11 nM.
EW-7197 (Vactosertib, TEW-7197) also inhibits ALK4 (IC50=13 nM) and shows less potency for p38α (IC50=280 nM).
EW-7197 (Vactosertib, TEW-7197) exhibits no inhibition on ALK1/2/3/6 (>10 uM).
EW-7197 (Vactosertib, TEW-7197) inhibits Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice.
EW-7197 (Vactosertib, TEW-7197) shows oral bioavailability (Hcl salt).

物理化学性质&存储条件

分子量	399.4236
分子式	C22H18FN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Imidazole-2-methanamine,N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-

参考文献

1. Jin CH, et al. J Med Chem. 2014 May 22;57(10):4213-38.

2. Son JY, et al. Mol Cancer Ther. 2014 Jul;13(7):1704-16.

3. Yoon JH, et al. EMBO Mol Med. 2013 Nov;5(11):1720-39.

EW-7197 (Vactosertib, EW7197, TEW-7197)

生物&药学活性

物理化学性质&存储条件

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EW-7197 (Vactosertib, EW7197, TEW-7197)

生物&药学活性

物理化学性质&存储条件

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